Differential pulse voltammetric simultaneous determination of acetaminophen and ascorbic acid using single-walled carbon nanotube-modified carbon-ceramic electrode
Habibi B., Jahanbakhshi M., Pournaghi-Azar M.H.
Volume 411, Issue 2, 2011
, Pages 167-175
=2.34 ,Quartile 2,Scopus2016
Single-walled carbon nanotube-modified carbon-ceramic electrode (SWCNT/CCE) was employed for the simultaneous determination of acetaminophen (APAP) and ascorbic acid (AA). The SWCNT/CCE displayed excellent electrochemical catalytic activities toward APAP and AA oxidation compared with bare CCE. In the differential pulse voltammetry technique, both AA and APAP gave sensitive oxidation peaks at -62 and 302 mV versus saturated calomel electrode, respectively. Under the optimized experimental conditions, APAP and AA gave linear responses over ranges of 0.2 to 150.0 Î¼M (R 2 = 0.998) and 5.0 to 700.0 Î¼M (R 2 = 0.992), respectively. The lower detection limits were found to be 0.12 Î¼M for APAP and 3.0 Î¼M for AA. The investigated method showed good stability, reproducibility, and repeatability as well as high recovery in pharmaceutical and biological samples. Â© 2011 Elsevier Inc. All rights reserved.